For specific information on the agents used in the management of rifampin, isoniazid, pyrazinamide, and ethambutol overdose, see pyridoxine systemic in monograph;.

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the objective of this review was to consolidate evidence from studies that examined any risk factors for acquired rifamycin and or isoniazid resistance in patients undergoing antitubercular therapy containing a rifamycin at least during the intensive phase.

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daniel fitzgerald, study co-author, this study reveals that a six-month course of the drug rifampicin followed by a year of isoniazid effectively decreases the risk of recurrent tuberculosis in this population.

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for isoniazid-resistant strains in hiv-infected patients, guidelines suggest rifampin or rifabutin plus ethambutol, pyrazinamide, and a quinolone levofloxacin moxifloxacin for the first 2 months, then rifampin or rifabutin , ethambutol, and a quinolone levofloxacin moxifloxacin for 7 months.


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