Large granular lymphocyte syndromekey concept objective to understand the various causes of neutropenia in rheumatoid arthritiswith the exception of prednisone, each of the listed factors can lead to neutropenia inpatients with rheumatoid arthritis.

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however, others point out that both prednisone and alcohol have the ability to irritate the stomach, leading to possible stomach ulcers or gastrointestinal system irritation.

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prednisone alternating with cyclosporine has been recommended at doses of prednisone 1 mg kg day po plus cyclosporine 10 mg kg day po in 2 divided doses based on actual or ideal body weight, whichever is lower.


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