In a clinical study of 15 male subjects ages 19 to 35 years who were extensive metabolizers of cyp2d6, bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the cmax, auc, and t of desipramine by an average of approximately 2-, 5-, and 2-fold, respectively.

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there are 2 hypotheses regarding bupropion-associated psychosis.

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the bupropion sr quit rate was also superior to placebo.

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in animal experiments bupropion doses several times higher than therapeutic doses in humans caused, amongst others, the following dose-related symptoms ataxia and convulsions in rats, general weakness, trembling and emesis in dogs and increased lethality in both species.

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smokers are at increased risk of cardiovascular death and early symptoms of cardiovascular disease may prompt therapy with bupropion.

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at eight weeks, the bupropion group effectively lost more weight than the placebo group and medication responders went on to successfully lose weight for up to two years after the initial eight week trial.


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