The absolute bioavailability of a 500 mg metformin hydrochloride tablet given under fasting conditions is approximately 50 to 60 .

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in the presence of normal renal function, there are no differences between single- or multiple-dose pharmacokinetics of amaryl m metformin hydrochloride between patients with type 2 diabetes and normal subjects see table 1 , nor is there any accumulation of amaryl m metformin hydrochloride in either group at usual clinical doses.
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