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coumadin has a narrow therapeutic range index , and its action may be affected by factors such as other drugs and dietary vitamin k.

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while coumadin is contraindicated during pregnancy, the potential benefits of using coumadin may outweigh the risks for pregnant women with mechanical heart valves at high risk of thromboembolism.

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patients taking coumadin should avoid drastic changes in dietary habits, such as eating large amounts of green leafy vegetables.

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consult the labeling of all concurrently used drugs to obtain further information about interactions with coumadin or adverse reactions pertaining to bleeding.


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