Falagas and gorbach 3 recommended clindamycin for the treatment of osteomyelitis due to s aureus and anaerobes, particularly if associated with diabetes or decubitus ulcers.

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it was observed that macrolides erythromycin and macrolide-like agents azm, clindamycin, telithromycin , at sub-mic concentrations, were potent inhibitors of pneumolysin production by both susceptible and resistant strains of streptococcus pneumoniae , with doxycycline being somewhat less effective, while amoxicillin, ceftriaxone, and tobramycin were ineffective.

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prompt surgical debridement of necrotic tissue is the mainstay of therapyadjuvant antibiotic therapy with high-dose penicillin g has been routinely recom-mended; studies have demonstrated that combination therapy with clindamycinappears superior to penicillin alone.

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clindamycin is excreted in breast milk and should not be used by nursing mothers or nursing should be stopped.

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furthermore, it is noteworthy that the antibiotics with anti-mrsa activity ie, tmp-smx and clindamycin had numerically lower failure rates than cephalexin, although the cephalexin cohort was small.


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