These peaks corresponded to the parent drug and metabolites, which indicated the partial and the extensive degradation of metoprolol and propranolol, respectively.

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the risk of peripheral ischemia, resulting in cold extremities or gangrene, has been reported to be increased when ergotamine or dihydroergotamine is coadministered with selected beta-blockers, including propranolol, a beta-blocker commonly used for migraine prophylaxis.

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administration of zolmitriptan or rizatriptan with propranolol resulted in increased concentrations of zolmitriptan auc increased by 56 and cmax by 37 or rizatriptan the auc and cmax were increased by 67 and 75 , respectively .

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