In the cpu, approximately 25 of cells showed mecp2 and mbd1 immunoreactivity in control rats; the percentage of mecp2 immunoreactive cells increased dramatically to 85 and 67 in response to fluoxetine and cocaine, respectively, whereas that of mbd1-positive cells rose to 70 and 60 fig.

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in the first continuous dosing double blind, parallel group study of 6 months duration involving n 320 patients, fixed doses of fluoxetine 20 and 60 mg day given daily throughout the menstrual cycle were shown to be significantly more effective than placebo as measured by a visual analogue scale vas total score including mood and physical symptoms .

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